Propylene Glycol
Allergic contact dermatitis is a T-cell dependent, delayed-type (Type IV) hypersensitivity reaction that has a high impact both in terms of patient morbidity and economics. This type of hypersensitivity reaction is primarily instigated by small lipophilic chemicals (haptens) with a molecular weight less than 500 Daltons. These chemical allergens trigger a complex immunologic cascade in the skin, which leads to the clinical picture of propylene glycol allergic contact dermatitis.
“Propylene glycol is a colorless, odorless organic compound that is used in many commercial products, as a moisturizer or humectant. Because of this property, to help keep products moist, you’ll find it in many personal care products and processed foods. These might include lotions, shampoos, conditioners, make-up, toothpaste and many food products you would typically expect to be moist.”
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“It is one of the most widely used ingredients in cosmetics, fragrances and various personal care products. PG functions as a solvent, emulsifier, preservative, vehicle, humectant and/or penetration enhancer. Propylene glycol can be also found in food, beverages, pharmaceutical preparations, electrocardiogram gels, household cleansers, pet foods, photographic chemicals, plasticizer and liquid cooling systems.“
